Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program
نویسندگان
چکیده
منابع مشابه
Naturally occurring anti-cancer agents targeting EZH2.
Natural products are considered as promising tools for the prevention and treatment of cancer. The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase unit of polycomb repressor complexes such as PRC2 complex that has oncogenic roles through interference with growth and metastatic potential. Several agents targeting EZH2 has been discovered but they often induce side effects in cl...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04864-8